Xeomin Treatment Areas, and the 64 Unit Ceiling

By Lucas, Founder & Lead Researcher

Reviewed for medical accuracy against our Medical Review Board  ·  Last updated 5 September 2026

Part of Botox vs Other Brands

Xeomin is approved for three areas of the face, and its label sets a combined maximum of 64 Units when all three are treated in one session. Both of those numbers are more specific than the equivalents for most of the class.

1. The three approved areas

Section 1.5 of the label groups them as upper facial lines: glabellar lines, horizontal forehead lines and lateral canthal lines. Frown lines, forehead lines and crow's feet, in ordinary language.

That is one area more than Dysport, Jeuveau, Daxxify and Letybo, which are each approved for frown lines only, and one fewer than Botox Cosmetic, which adds platysma bands in the neck. Our comparison of approved areas across all six has the full table.

2. Frown lines

Five intramuscular injections of 4 Units each: two into each corrugator muscle and one into the procerus, for 20 Units total.

The label attaches two specific instructions to reduce the risk of a drooping eyelid, and they are worth knowing because they describe what good technique looks like here:

• Avoid injecting near the levator palpebrae superioris, the muscle that holds your upper eyelid up, and take particular care in people with larger brow depressor complexes.
• Place the corrugator injections at least 1 cm above the bony supraorbital ridge, meaning at least a centimetre above the bone you can feel along your brow.

Ptosis is the complication those rules exist to avoid, and it is the most common adverse reaction reported for this area across the class.

3. Forehead lines, which cannot be treated alone

This is the instruction most likely to be skipped at a consultation, and the label is unambiguous: treat horizontal forehead lines in conjunction with glabellar lines to minimise the potential for brow ptosis.

So the approved forehead treatment is 20 Units in the forehead plus 20 Units in the frown lines, 40 Units together. Not 20 on its own.

The reason is mechanical rather than commercial. The frontalis muscle across your forehead is the only muscle lifting your brow. The glabellar complex pulls it down. Relax the lifter while leaving the depressors at full strength and the brow sits lower than it started, which reads as a heavy or hooded look. Treating both keeps the balance.

The five forehead injections are placed horizontally into the frontalis, 4 Units each, at least 2 cm above the orbital rim. That distance is the other half of the same protection.

If you are quoted forehead-only treatment at 8 or 12 Units, you are not being offered a smaller version of the approved protocol. You are being offered a different one, and the label names the risk it carries.

4. Crow's feet

Four Units into each of three sites per side, six injection points in total, for 24 Units. That is 12 Units per side.

Xeomin and Botox Cosmetic are the only two of the six approved for this area, and their approved doses are the same number, which is a coincidence of dosing rather than evidence that the units are equivalent. They are not. The label states plainly that units of one product cannot be converted into units of another, and our conversion guide covers why.

5. The 64 Unit ceiling

Treating all three areas in one session has a stated maximum: 64 Units, made up of 20 for frown lines, 20 for forehead lines and 24 for crow's feet.

That is a useful number to hold, because it gives you something almost nobody has for cosmetic treatment: a labelled upper bound for a full upper-face session. If a quote for those three areas comes in materially above 64 Units, that is a question worth asking rather than a sign of generosity. Our Xeomin cost page covers what that translates to in money.

Retreatment, as with every product in the class, is no more frequently than every three months.

6. Everywhere else is off-label

Masseter, jawline, chin, lip flip, bunny lines, neck bands, under the eyes: none of these is an approved Xeomin indication. Treatment there is off-label, which is legal, common and often reasonable, and which means the dose is convention rather than protocol.

Two things follow that are worth saying plainly. There is no labelled dose to check a quote against, so the number you are given rests on your injector's experience. And Xeomin's specific claim, that removing accessory proteins matters for long-term response, is a claim about the molecule rather than about any particular area. The Xeomin guide works through what that claim is and is not evidence for, and how long it lasts covers duration by area.

Frequently asked questions

Written by

Lucas Pradella

Founder & Lead Researcher, BestBotoxClinics.com

Lucas founded BestBotoxClinics.com to bring clarity to the aesthetics industry, bringing 13+ years of experience in digital research and analysing online data for signals of quality and trust. He is not a physician, his work is research, data analysis and verifying provider credentials.

More about Lucas  ·  How we work

Medical accuracy: BestBotoxClinics.com maintains a Medical Review Board of licensed clinicians. This article is educational and is not medical advice.

Know the count before the quote. The unit count is half the bill, and a low per-unit rate recovered by a high unit count is the commonest way a deal is not one. How to tell.

Deciding which area, not how many units? Botox by facial area covers what each zone actually achieves, which four are FDA approved, and the things Botox cannot fix at all.

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