Where to Get Xeomin, and the Storage Rule That Decides Who Carries It
Reviewed for medical accuracy against our Medical Review Board · Last updated 5 September 2026
Part of Botox vs Other Brands
One line in the Xeomin label does more to determine where you can get it than any marketing decision: refrigeration of unopened vials is not required.
1. The storage rule, and why it matters to you
Section 16 of the Xeomin prescribing information says to store unopened vials at or below 25 degrees Celsius, and states plainly that refrigeration of unopened vials is not required. Every other product in the class needs a fridge, or at minimum offers refrigeration as one of two options.
That is not a clinical advantage to you. The drug is not better for it. What it changes is the economics of carrying it. A practice that treats a few patients a week does not need a dedicated medical fridge, does not need to manage a cold chain on delivery, and carries less risk of losing stock to a temperature excursion. So Xeomin turns up in a wider range of settings than its market share alone would suggest, including smaller practices and newer injectors.
Once reconstituted it goes in the fridge like everything else, at 2 to 8 degrees, for up to 24 hours until use.
The practical consequence: if a clinic tells you they cannot get Xeomin, that is a supplier relationship or a preference, not a storage constraint.
2. Xeomin covers more of your face than most of the class
Xeomin is approved for three cosmetic areas: frown lines, horizontal forehead lines and crow's feet. Only Botox Cosmetic covers more. Dysport, Jeuveau, Daxxify and Letybo are each approved for frown lines and nothing else.
So if you are treating the upper face as a whole, Xeomin and Botox Cosmetic are the two products where the entire treatment is on-label. Our treatment areas page has the doses, including the 64 Unit ceiling for all three areas together.
3. The rewards programme, and the fine print
Merz runs Xperience+, which advertises $50 instant savings on a treatment, limited to once every 90 days per patient, and up to $240 a year. Read the qualifier Merz attaches: the instant saving is issued at the discretion of a participating provider. So it depends on the clinic, and it is worth asking whether they participate before you book rather than at the till. Our guide to discounts covers how the programmes compare.
4. The checks that apply to any brand
Licence verification, spotting a diverted vial and the questions to ask do not change by product, so rather than repeat them: our provider verification guide covers the databases, the state boards and the red flags, and our unapproved toxins page covers what a price well below the market usually means. The one check worth making anywhere is to ask for the lot number to be written into your notes.
5. The one Xeomin claim to interrogate
Xeomin is sold on being the pure or naked toxin: it is manufactured to remove the accessory proteins that the other products carry, on the argument that fewer foreign proteins means less chance of your immune system learning to neutralise it.
The manufacturing difference is real and is described in the label. What is worth pressing on is the conclusion drawn from it. Across 2,649 patients in Xeomin trials, 0.3% were positive for neutralizing antibodies with an unknown baseline and a further 0.2% developed them, and the label adds that no patient showed a secondary loss of response because of them. That is a good result. It is also not very different from what the other products report at cosmetic doses: Botox Cosmetic found none in 916 subjects, and Dysport found none in 1,554 across up to nine treatment cycles.
So the fair reading is that resistance is rare across the class, and Xeomin's formulation gives it a plausible mechanism rather than a demonstrated advantage. If a clinic recommends it specifically because you have "stopped responding" to Botox, that is worth a longer conversation about dose first. The Xeomin guide works through the evidence in full.
Frequently asked questions
Do clinics need to refrigerate Xeomin?
Why do some clinics carry Xeomin and not Botox?
Is Xeomin good if Botox stopped working for me?
Can I get my whole upper face done with Xeomin?
Sources
Every figure on this page was read from the documents below rather than from a clinic or a manufacturer's marketing. They open in a new tab so you can check any claim here against its source.
- Xeomin prescribing information, US National Library of Medicine, DailyMed
- FDA-approved botulinum toxin products, US Food and Drug Administration
Know the count before the quote. The unit count is half the bill, and a low per-unit rate recovered by a high unit count is the commonest way a deal is not one. How to tell.
Deciding which area, not how many units? Botox by facial area covers what each zone actually achieves, which four are FDA approved, and the things Botox cannot fix at all.
