Botox vs Other Neurotoxin Brands
“Botox” has become the word people use for any wrinkle-relaxing injection, but it is one brand among many. Eleven botulinum toxin type A products are compared here, six you can legally receive in the United States, and five you cannot.
See all 13 guidesAll of these products work the same way: they block the nerve signal that tells a muscle to contract, which softens the lines that muscle creates. What separates them is formulation, how far the product spreads from the injection point, how long the effect lasts, and, most practically, whether a clinic in your country can legally buy it.
The single most useful distinction is availability. Botox, Dysport, Xeomin, Jeuveau, Daxxify and Letybo are FDA-approved and sold to licensed US providers. Neuronox, Innotox, Liztox, Coretox and Rentox are widely used in South Korea and other markets but are not approved for sale in the United States. If a US clinic offers you one of those five, that is a serious warning sign about where their product is coming from.
At a glance
| Brand | Available in the US | Typical duration | What sets it apart |
|---|---|---|---|
| Botox | Yes, FDA approved | 3–4 months | The reference product. FDA approved for medical use in 1989 and cosmetic use in 2002. |
| Dysport | Yes, FDA approved | 3–4 months | Spreads slightly further from the injection point, which some injectors prefer on larger areas like the forehead. |
| Xeomin | Yes, FDA approved | 3–4 months, some report 5–6 | The “naked” toxin, no complexing proteins, which may reduce antibody resistance over long-term use. |
| Jeuveau | Yes, FDA approved | 3–4 months | Approved for cosmetic use only. Manufactured by Daewoong and sold as Nabota outside the US. |
| Daxxify | Yes, FDA approved | 6–9 months | Uses a peptide stabiliser instead of animal or human proteins. Much the longest-lasting option. |
| Letybo | Yes, FDA approved | 3–4 months | The newest FDA-approved toxin in the US, approved for frown lines. |
| Nabota | Yes, as Jeuveau | 3–4 months | The same product as Jeuveau. Made by Daewoong in South Korea, launched in the US in 2019 under the Jeuveau name. |
| Neuronox | No | 3–4 months | Widely used in South Korea and Southeast Asia. Not approved for US sale. |
| Innotox | No | 3–4 months | Ships as a pre-mixed liquid rather than a powder needing reconstitution. Not approved for US sale. |
| Liztox | No | 3–4 months | A newer Korean toxin. Not approved for US sale. |
| Coretox | No | 3–4 months | Formulated without animal-derived proteins. Not approved for US sale. |
| Rentox | No | 3–4 months | Korean botulinum toxin type A. Not approved for US sale. |
How to choose
- If you want the longest gap between appointments
- Daxxify is the only product here lasting 6–9 months rather than 3–4. Fewer sessions a year, though the per-session price is usually higher and not every clinic stocks it.
- If you have stopped responding to Botox
- A small number of long-term patients develop antibodies that blunt the effect. Xeomin contains no complexing proteins, which is the reason injectors often suggest it in that situation.
- If you are treating a large area like the forehead
- Dysport’s slightly wider spread can mean smoother coverage across a broad muscle. On small, precise areas that same property is a drawback, which is why many injectors keep both.
- If price is the deciding factor
- Compare the total for your treatment, not the per-unit rate. Dysport units are not equivalent to Botox units, a comparable result typically needs roughly two and a half to three times as many, so a lower unit price does not mean a lower bill.
- If a clinic offers you a toxin not approved here
- Neuronox, Innotox, Liztox, Coretox and Rentox cannot be legally sold to US providers. Being offered one means the product was obtained outside the regulated supply chain, with no guarantee of what is in the vial.