📅 2 September 2026🏷 Other Neurotoxins

Jeuveau by Area and Units: 20 Units, Five Sites, and One Approved Region

By Lucas, Founder & Lead Researcher

Reviewed for medical accuracy against our Medical Review Board · Last updated 2 September 2026

If you searched for Jeuveau for forehead wrinkles, here is the answer before anything else. Jeuveau is not approved for the forehead. It is approved for one area of the face and one only, and the label is unusually blunt about it.

That does not mean no injector will do it. It means there is no reviewed dose, no reviewed injection map and no trial data for it, with this product, in that place.

The only labelled dose Jeuveau has. 20 Units total for the glabellar lines: 0.1 mL, which is 4 Units, into each of five sites, one in the procerus and two in each corrugator supercilii. For the forehead, crow's feet, masseter, chin, neck or anything else, there is no labelled Jeuveau dose at all, because there is no approval to attach one to.

The one approved area, and the exact dose

Jeuveau, which is prabotulinumtoxinA-xvfs, is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and procerus muscle activity, in adults. Glabellar lines are the vertical "11s" between the brows.

The dose is fixed and specific:

Area	Labelled Jeuveau dose	Sites	Per site
Glabellar lines	20 Units	5	0.1 mL = 4 Units
Forehead lines	No labelled dose. Not an approved indication
Crow's feet	No labelled dose. Not an approved indication
Any other area	No labelled dose. Not an approved indication

Unlike Botox, which holds approvals for four cosmetic areas, and unlike Dysport, whose approved and off-label areas we set out separately, Jeuveau's approval covers a single region. That is not a defect. It is a narrower approval, and knowing it changes what questions are worth asking.

Where the five injections go

The label specifies the anatomy, not just the number. The five injections are:

One into the procerus, the small muscle running vertically between the brows over the bridge of the nose. It pulls the brows down and inward.
Two into each corrugator supercilii, the paired muscles above each eyebrow that draw the brows together. That is four injections, two per side.

Each is 0.1 mL, containing 4 Units. Total 20 Units, delivered intramuscularly.

Two things follow from that map. First, the injections sit close to the levator muscle that lifts the upper eyelid, which is why eyelid ptosis was the one adverse reaction the trials attributed to the drug, at 2% against 0% on placebo. Injection depth and placement are what manage that risk, which is a reason to care who is holding the syringe. See droopy eyelid after Botox, which applies across this class.

Second, the dose is per treatment, not per side, and the label instructs that retreatment be no more frequent than every three months with the cumulative dose taken into account. For what the label does and does not say about how long it lasts, see how long Jeuveau lasts.

Jeuveau for the forehead, and what off-label means

This is the search that brings most people here, so it deserves a straight answer rather than a hedge.

A forehead treatment with Jeuveau is off-label. The label's boxed warning states that "JEUVEAU is not approved for the treatment of spasticity or any conditions other than glabellar lines." Most products' labels leave the boundary implied. This one names it in the most prominent warning it has.

What off-label actually means, stated plainly:

It is legal. A licensed prescriber may use an approved drug outside its approved indication where they judge it appropriate. This happens constantly across medicine.
It is common. Forehead lines and the glabella are usually treated together, because the muscles interact: relax the glabella alone and the frontalis can pull differently.
There is no reviewed dose. No regulator has assessed how many units of this product belong in a frontalis, or at what depth, or with what safety profile.
There is no trial evidence for it. EV-001 and EV-002 studied glabellar lines only. The 68% and 70% success figures do not transfer to an area that was not studied.

If a labelled forehead dose matters to you, Botox Cosmetic is the product that has one, and our page on Botox for forehead lines goes through it. That is a genuine reason to pick one product over another, and a better reason than a promotion.

Every other area people ask about

The honest position on all of these is identical, so rather than pad it out: with Jeuveau, each is off-label, has no labelled dose, and has no trial data behind it.

Crow's feet, the lateral canthal lines. Botox has an approved dose here. Jeuveau does not. See Botox for crow's feet.
Masseter, for jaw slimming or clenching. Off-label for every neurotoxin including Botox, and a much larger dose than any cosmetic area. See masseter Botox.
Lip flip, bunny lines, chin, neck bands, gummy smile, brow lift. All off-label with Jeuveau.
Hyperhidrosis, migraine, and any other medical use. Explicitly outside this product's approval, per the boxed warning. Botox holds those indications; Jeuveau holds none.

For a full picture of which areas have an FDA-reviewed dose and which do not, across products, our units per area chart lays it out.

Why 20 units of Jeuveau is not 20 units of anything else

This trips up almost every price comparison, and the label is explicit about it.

Jeuveau's potency is set by an animal-based assay specific to the manufacturer's own product, in which one Unit corresponds to the calculated median lethal dose in mice under that assay. Because the assay is product-specific, the label states that Jeuveau units cannot be converted into units of any other botulinum toxin assessed by any other method. Every product in this class carries the same statement about itself.

So "20 units" is not a fixed quantity of effect. It is a fixed quantity of this product measured this way. A clinic offering 20 units of one brand for less than 20 units of another is not necessarily offering you less or more relaxation. The only comparison that holds is the total price to treat your area with the labelled dose of whichever product you choose. We put all six brands' labelled doses side by side on the unit conversion page.

What to ask if a non-approved area is proposed

Is this area inside Jeuveau's approval? Only the glabella is. A good injector will say so without being pushed.
Why this product for this area, rather than one with a labelled dose there? Sometimes the answer is genuinely good, such as your own history with it. Sometimes it is stock.
How many units, where, and how did you arrive at that? There is no label to cite outside the glabella, so the answer is their clinical judgement, which is worth hearing stated.
What is the plan if my brow drops? Ptosis is the reaction the trials attribute to the drug in the area it is approved for.
When can I be treated again? Three months is the label's floor regardless of area.
Can I verify your licence? You can, in all fifty states, in about two minutes. See how to verify an injector's licence.

For everything the Jeuveau label contains, including the placebo column nobody quotes, see our full Jeuveau guide. The area itself, across all products, is covered on frown lines and the glabella.

Frequently asked questions

Can Jeuveau be used on the forehead?

It can be injected there, but it is off-label. Jeuveau is FDA-approved for glabellar lines only, and its boxed warning states that it is not approved for the treatment of spasticity or any conditions other than glabellar lines. So there is no labelled dose for the forehead, no reviewed injection map, and no trial data: EV-001 and EV-002 studied the glabella alone. Off-label use is legal and common, and Botox Cosmetic is the product that does hold a labelled forehead dose if that matters to you.

How many units of Jeuveau do I need?

For the one area it is approved for, 20 Units in total. The label specifies 0.1 mL, which is 4 Units, into each of five sites: one injection into the procerus muscle and two into each corrugator supercilii. For any other area there is no labelled Jeuveau dose, because there is no approval to attach one to.

Is 20 units of Jeuveau the same as 20 units of Botox?

No, and the label says so directly. Jeuveau potency is measured by an assay specific to its own manufacturer, where one Unit is the calculated median lethal dose in mice under that assay. Because the assay is product-specific, the label states that Jeuveau units cannot be converted into units of any other botulinum toxin. A unit is not a portable measure of effect, which is why per-unit price comparisons between brands are misleading.

Where exactly does Jeuveau get injected?

Five sites for the glabellar lines. One injection goes into the procerus, the muscle running vertically between the brows over the bridge of the nose, and two go into each corrugator supercilii, the paired muscles above each brow that pull them together. That is four corrugator injections plus one procerus injection, each 0.1 mL containing 4 Units.

Can Jeuveau treat crow's feet or the masseter?

Both would be off-label with Jeuveau, which has no approval or labelled dose outside the glabella. For crow's feet, Botox holds an approved dose for the lateral canthal lines. The masseter is off-label for every neurotoxin including Botox, and uses a considerably larger dose than any cosmetic facial area.

Why does Jeuveau only have one approved area?

Because that is what its manufacturer sought and what the trials supported. Evolus has no medical product line, and Jeuveau was developed and approved as a cosmetic treatment for glabellar lines. A narrower approval is not a safety judgement about the product; it reflects which indications were studied and submitted.

Sources

Every figure on this page was read from the documents below rather than from a clinic or a manufacturer's marketing. They open in a new tab so you can check any claim here against its source.

JEUVEAU (prabotulinumtoxinA-xvfs) for injection, full prescribing information, US National Library of Medicine, DailyMed
FDA-approved botulinum toxin products, US Food and Drug Administration

Written by

Lucas Pradella

Founder & Lead Researcher, BestBotoxClinics.com

Lucas founded BestBotoxClinics.com to bring clarity to the aesthetics industry, bringing 13+ years of experience in digital research and analysing online data for signals of quality and trust. He is not a physician, his work is research, data analysis and verifying provider credentials.

More about Lucas · How we work

Medical accuracy: BestBotoxClinics.com maintains a Medical Review Board of licensed clinicians. This article is educational and is not medical advice.